Dan Ruderman

Dan Ruderman, PhD

Assistant Professor of Research Medicine

+1 323 442 2839
ruderman@usc.edu

Dan is an Assistant Professor of Research Medicine at the Keck School of Medicine of USC and the Lawrence J. Ellison Institute for Transformative Medicine of USC. He received his doctorate in theoretical physics from the University of California at Berkeley, followed by postdoctoral research at Cambridge University, USC, and the Salk Institute. He then continued his scientific research in the industrial setting, first in solid tumor target discovery through integrative genomics at Berlex Biosciences, and then in proteomic biomarker discovery at Applied Minds.

Dan was Founding Scientist at Applied Proteomics, a biomarker company spun out from Applied Minds in 2007. He joined the Ellison Institute in 2011 where his research focuses on signaling dynamics in cancer cells and systems biology interpretations of high-dimensional cancer assays, such as gene expression, proteomics, and autoantibodies.


Education

BA

1989 – Physics, University of California, Berkeley, CA

PhD

1993 Physics – University of California, Berkeley, CA

Fellowship

1993-1995 Postdoctoral Fellow – The Physiological Laboratory, Cambridge University, UK
1995-1996 Department of Biomedical Engineering – USC, Los Angeles, CA
1996-1998 Postdoctoral Fellow – Sloan Center for Theoretical Neuroscience, The Salk Institute


Research Focus

  • Intracellular dynamics
  • Intratumor heterogeneity
  • Digital pathology
  • Machine learning and statistical method

Awards

  • Sloan Foundation: Postdoctoral Fellowship, 1996-1998
  • National Science Foundation/ North Atlantic Treaty Organization: Postdoctoral Fellowship, 1994
  • Fannie and John Hertz Foundation: Fellowship, 1989-1993
  • National Science Foundation: Fellowship, 1993
  • Phi Beta Kappa: Elected Member, 1988
  • President’s Undergraduate Fellowship

Publications

Ruderman D. Designing Successful Proteomics Experiments. Methods Mol Biol. 2017;1550:271-288.View in: PubMed

Patsch K, Chiu CL, Engeln M, Agus DB, Mallick P, Mumenthaler SM, Ruderman D. Single cell dynamic phenotyping. Sci Rep. 2016 Oct 6;6:34785. View in: PubMed

Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016; 8(1):54. View in: PubMed

Chiu CL, Patsch K, Cutrale F, Soundararajan A, Agus DB, Fraser SE, Ruderman D. Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS). Sci Rep. 2016; 6:22435. View in: PubMed

Kani K, Malihi PD, Jiang Y, Wang H, Wang Y, Ruderman DL, Agus DB, Mallick P, Gross ME. Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15. View in: PubMed

Chambers MC, Maclean B, Burke R, Amodei D, Ruderman DL, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, Hoff K, Kessner D, Tasman N, Shulman N, Frewen B, Baker TA, Brusniak MY, Paulse C, Creasy D, Flashner L, Kani K, Moulding C, Seymour SL, Nuwaysir LM, Lefebvre B, Kuhlmann F, Roark J, Rainer P, Detlev S, Hemenway T, Huhmer A, Langridge J, Connolly B, Chadick T, Holly K, Eckels J, Deutsch EW, Moritz RL, Katz JE, Agus DB, Maccoss M, Tabb DL, Mallick P. A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 2012 Oct 10; 30(10):918-20. View in: PubMed

Hughey CA, Minardi CS, Galasso-Roth SA, Paspalof GB, Mapolelo MM, Rodgers RP, Marshall AG, Ruderman DL. Naphthenic acids as indicators of crude oil biodegradation in soil, based on semi-quantitative electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2008 Dec; 22(23):3968-76. View in: PubMed

Yamaguchi KD, Ruderman DL, Croze E, Wagner TC, Velichko S, Reder AT, Salamon H. IFN-beta-regulated genes show abnormal expression in therapy-naïve relapsing-remitting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions. J Neuroimmunol. 2008 Mar; 195(1-2):116-20. View in: PubMed

Tedesco D, Zhang J, Trinh L, Lalehzadeh G, Meisner R, Yamaguchi KD, Ruderman DL, Dinter H, Zajchowski DA. The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition. Neoplasia. 2007 Jul; 9(7):601-13. View in: PubMed

Mel BW, Ruderman DL, Archie KA. Translation-invariant orientation tuning in visual “complex” cells could derive from intradendritic computations. J Neurosci. 1998 Jun 1; 18(11):4325-34. View in: PubMed