Jerry S.H. Lee, PhD

Jerry S.H. Lee, PhD

Jerry S.H. Lee, PhD

Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences

Chief Science and Innovation Officer

+1 323 442 0458
dr.jerry@usc.edu

Dr. Lee is an Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the University of Southern California Keck School of Medicine and Viterbi School of Engineering. As the Chief Science and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine of USC, he provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century.

Prior to joining USC, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit.

In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues.

Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over thirty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.


Education

BS

2001 Biomedical Engineering – Johns Hopkins University, Baltimore, MD

PhD

2006 Chemical and Biomolecular Engineering- Johns Hopkins University, Baltimore, MD


Research Focus

  • Cell and tissue biophysics
  • Cell migration and motility
  • Data-driven molecular medicine
  • Adaptive learning healthcare system

Awards

  • National Cancer Institute Director’s Merit Award, 2010 – 2012, 2014 – 2017
  • NASA Graduate Student Research Fellowship Award, 2004 – 2006
  • Tau Beta Pi, 2004

Leadership Positions

  • Trustee, Health and Environmental Sciences Institute
  • Appointed Member, National Research Advisory Council to the Secretary, Department of Veterans Affairs
  • Innovation Initiative Member, Health Services Research and Development Scientific Merit Review Board, Department of Veterans Affairs
  • Founding Member, Innovation Policy Forum of the Board on Science, Technology, and Economic Policy, National Academies of Sciences, Engineering, and Medicine (NASEM)
  • Co-founder and Co-chair, Blood Profiling Atlas in Cancer (BloodPAC)
  • Co-founder and Consultant, Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Research Network, Henry M. Jackson Foundation
  • Founding Co-chair, High Content Data Integration Working Group, Biomarkers’ Consortium Cancer Steering Committee, Foundation for the National Institutes of Health

Publications

Eaglehouse, Yvonne L.,  Aljehani, Mayada,  Georg, Matthew W.,  Castellanos, Olga,  S. H. Lee, Jerry,  Seabury, Seth A.,  Shriver, Craig D.,  and Zhu, Kangmin . Contribution Of Care Source To Cancer Treatment Cost Variation In The US Military Health System. Health Affairs. 2019. View: here

Broderick, J.E., M. May, J.E. Schwartz, M. Li, A. Mejia, L. Nocera, A. Kolatar, N.T. Ueno, S. Yunnu, J.S.H. Lee, S.E. Hanlon, F.A. Cozzens Philips, C. Shahabi. P. Kuhn, J. Nieva.  Patient reported outcomes can improve performance status assessment: a pilot study.  Journal of Patient-Reported Outcomes.  2019.  View: here

Rivera, D., J.S.H. Lee, E. Hsu, M. Khoury, F. Meng, O. Olivero, L. Penberthy, G. Tourassi.  Harnessing the Power of Collaboration and Training within Clinical Data Science to Generate Real World Evidence in the Era of Precision Oncology.  Clinical Pharmacology and Therapeutics, 2019. View: here

Lee, J.S.H., K.M. Darcy, H. Hu, Y. Casablanca, T.P. Conrads, C.L. Dalgard, J.B. Freymann, S.E. Hanlon, G.D. Huang, L. Kvecher, G.L. Maxwell, F. Meng, J. Moncur, C. Turner, J.M. Wells, M.D. Wilkerson, K. Zhu, R.B. Ramoni, C.D. Shriver.  From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients.  Clinical Pharmacology and Therapeutics, 2019. View: here

Lee J.S.H., Kibbe W.A., Grossman R.L. Data Harmonization for a Molecularly Driven Health System. Cell, 2018. View in: PubMed

Piehowski P.D., Petyuk V.A., Sontag R.L., Gritsenko M.A., Weitz K.K., Fillmore T.L., Moon J., Makhlouf H., Chuaqui R.F., Boja E.S., Rodriguez H., Lee J.S.H., Smith R.D., Carrick D.M., Liu T., Rodland K.D. Residual Tissue Repositories as a Resource for Population-based Cancer Proteomic Studies. Clinical Proteomics. 2018. View in: PubMed

Jayatilaka H., F.G. Umanzor, V. Shah, T. Meirson, G. Russo, B. Starich, P. Tyle, J.S.H. Lee, S. Khatau, H. Gil-Henn, D. Wirtz. Tumor cell density regulates matrix metalloproteinases for enhanced migration. Oncotarget. 2018. View: here

Wu P.H., Aroush D.R., Asnacios A., Chen W.C., Dokukin M.E., Doss B.L., Durand-Smet P., Ekpenyong A., Guck J., Guz N.V., Janmey P.A., Lee J.S.H., Moore N.M., Ott A., Poh Y.C., Ros R., Sander M., Sokolov I., Staunton J.R., Wang N., Whyte G., Wirtz D. A Comparison of Methods to Assess Cell Mechanical Properties. Nature Methods. 2018. View in: PubMed

Keating, S.M., D.L. Taylor, A.L. Plant, E. Litwack, P. Kuhn, E.J. Greenspan, C.M. Hartshorn, C.C. Sigman, G.J. Kelloff, D. Chang, G. Friberg, *J.S.H. Lee, *K. Kuida. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clinical and Translational Science. 2018. View in: PubMed

Kowak, E., P. Multani, W. McCarthy, Z. Hornby, G. Li, R. Landin, M. Yamamoto, J. Christiansen, J.S.H. Lee, J. Lim. Innovative Methodologies to Drive Enrollment of Molecularly Defined Patient Populations for Diagnostic-Enabled Basket Studies. Journal of Precision Medicine. 2017. View: here

Lee, J.S.H., G.M. Blumenthal, R.J. Hohl, S-M Huang. Cancer Therapy: Shooting for the Moon. Clinical Pharmacology and Therapeutics. 2017. View in: PubMed

Sharma, P., C. Ng., A. Jana, A. Padhi, P. Szymanski, J.S.H. Lee, B. Behkam, A. Nain. Aligned Fibers Direct Collective Cell Migration to Engineer Closing and Non-Closing Wound Gaps. Molecular Biology of the Cell, 2017. View in: PubMed

Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz. Biophysical and Biomolecular Determination of Cellular Age in Humans. Nature Biomedical Engineering. 2017. View: here

Jayatilaka H.U., P. Tyle, J. Chen, M. Kwak, J. Ju, H.J. Kim, J.S.H. Lee, P.H. Wu., D. Gilkes, R. Fan, D. Wirtz. Novel Synergistic IL6/8 Paracrine Signaling Pathway Infers New Strategy to Inhibit Tumor Cell Migration. Nature Communications. 2017. View in: PubMed

Elder, S.G. and J.S.H. Lee. Advancing Convergence and Innovation in Cancer Research: National Cancer Institute Center for Strategic Scientific Initiatives (CSSI). Electrochemical Society Transactions. 2017. View: here

Grossman, R.L., B. Abel, S. Angiuoli, J.C. Barrett, D. Bassett, K. Bramlett, G.M. Blumenthal, A. Carlsson, R. Cortese, J. DiGiovanna, B. Davis-Dusenbery, R. Dittamore, D.A. Eberhard, P. Febbo, M. Fitzsimons, Z. Flamig, J. Godsey, J. Goswami, A. Gruen, F.O. Guzman, J. Han, D. Hayes, J. Hicks, D. Holloway, D. Hovelson, J. Johnson, H. Juhl, R. Kalamegham, R. Kamal, Q. Kang, G.J. Kelloff, M. Klozenbuecher, A. Kolatkar, P. Kuhn, K. Langone, R. Leary, P. Loverso, H. Manmathan, A-M Martin, J. Martini, D. Miller, M. Mitchell., T. Morgan, R. Mulpuri, T. Nguyen, G. Otto, A. Pathak, E. Peters, R. Philip, E. Posadas, D. Reese, M.G. Reese, D. Robinson, A.D. Rossi, H. Sakul, J. Schageman, S. Singh, H.I. Scher, K. Schmitt, A. Silvestro, J. Simmons, T. Simmons, J. Sislow, A. Talasaz, P. Tang, M. Tewari, S. Tomlins, H. Toukhy, H.R. Tseng, M. Tuck, A. Tzou, J. Vinson, Y. Wang, W. Wells, A. Welsh, J. Wilbanks, J. Wolf, L. Young, J.S.H. Lee, L.C. Leiman. Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium. Clinical Pharmacology and Therapeutics. 2017. View in: PubMed

Kievit, F.M., S. J. Florczyk, M.C. Leung, K. Wang, J.D. Wu, J.R. Silber, R.G. Ellenbogen, J.S.H. Lee, M. Zhang. Proliferation and Enrichment of CD133(+) Glioblastoma Cancer Stem Cells on 3D Chitosan-alginate Scaffolds. Biomaterials. 2014. View in: PubMed

Carr, S.A., S.E. Abbatiello, B.L. Ackermann, C. Borchers, B. Domon, E.W. Deutsch, R.P. Grant, A.N. Hoofnagle, R. Huttenhain, J.M. Koomena, D.C. Liebler, T. Liu, B. MacLean, D.R. Mani, E. Mansfield, H. Neubert, A.G. Paulovich, L. Reiter, O. Vitek, R. Aebersold, L. Anderson, R. Bethem, J. Blonder, E. Boja, J. Botelho, M. Boyne, R.A. Bradshaw, A.L. Burlingame, D. Chan, H. Keshishian, E. Kuhn, C. Kinsinger, J.S.H. Lee, S. Lee, R. Moritz, J. Oses-Prieto, N. Rifaio, J. Ritchiep, H. Rodriguez, P.R. Srinivas, R.R. Townsend, J. Van Eyk, G. Whiteley, A. Wiita, S. Weintraubt. Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach . Molecular and Cellular Proteomics. 2014. View in: PubMed

Dawson, M., Y. Tseng, J.S.H. Lee, K.M. McAndrews. Intracellular Particle Tracking Rheometry. CRC Handbook of Imaging in Biological Mechanics. 2014.

Chen, W.C., P.H. Wu, J.M. Phillip, S.B. Khatau, J.M. Choi, M.R. Dallas, K. Konstantopoulos, S.X. Sun, J.S.H. Lee, D. Hodzic, D. Wirtz. Functional Interplay Between the Cell Cycle and Cell Phenotypes. Intergrative Biology. 2013. View in: PubMed

Hsu, E.R., D.E. Williams, L. DiJoseph, J.D. Schnell, S.L. Finstad, J.S.H. Lee, E.J. Greenspan, J.G. Corrigan. Rapid and automated assessment of new biomedical research funding initiatives: application to the National Cancer Institute’s Provocative Question initiative. Research Evaluation. 2013. View in: PubMed

Scott, D., W. Tan, J.S.H. Lee, O.J.T. McCarty, M.T. Hinds. Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction. Mechanical and Chemical Signalling in Angiogenesis, Studies in Mechanobiology, Tissue Engineering, and Biomaterials. 2013.

Kievit, F.R., A. Cooper, S. Jana, M.C. Leung, K. Wang, D. Edmondson, D. Wood, J.S.H. Lee, R.G. Ellenbogen, M. Zhang. Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Advanced Healthcare Materials. 2013. View in: PubMed

Khatau, S.B., S. Kusuma, D. Hanjaya-Putra, P. Mali, L. Cheng, J.S.H. Lee, S. Gerecht, D. Wirtz. The Differential Formation of the LINC-mediated Perinuclear Actin Cap in Pluripotent and Somatic Cells. PLoS ONE. 2012. View in: PubMed

Parkinson, D.R., N. Dracopoli, B.G. Petty, C. Compton, M. Cristofanilli, A. Deisseroth, D.F. Hayes, G. Kapke, P. Kuman, J.S.H. Lee, M.C. Liu, R. McCormack, S. Mikulski, L. Nagahara, K. Pantel, S. Pearson-White, E. Punnoose, L. Roadcap, A.E. Schade, H.I. Scher, C.C. Sigman, G.J. Kelloff. Considerations in the Development of Circulating Tumor Cell Technology For Clinical Use. Journal of Translational Medicine. 2012. View in: PubMed

Wu, P.H., C.M. Hale, W.C. Chen, J.S.H. Lee, Y. Tseng, D. Wirtz. High-throughput Ballistic Injection Nanorheology to Measure Cell Mechanics . Nature Protocols. 2012. View in: PubMed

Hale, C.M., W.C. Chen, S.B. Khatau, B.R. Daniels, J.S.H. Lee, D. Wirtz. SMRT Analysis of MTOC and Nuclear Positioning Reveals the Role of EB1 and LIC1 in Single-cell Polarization. Journal of Cell Science. 2011. View in: PubMed

Fraley, S.I., C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, D. Wirtz. Intra- and Extracellular Microrheology of Endothelial Cells in 3D Matrix. Biological and Medical Physics, Biomedical Engineering: Biophysical Regulation of Vascular Differentiation and Assembly. 2011.

Lee, J.S.H. and D. Wirtz. Physical Oncology. Physical Biology, 2011. View in: PubMed

Moore, N.M., N.Z. Kuhn, S.E. Hanlon, J.S.H. Lee, L.A. Nagahara. De-convoluting cancer’s complexity: using a ‘physical sciences lens’ to provide a different (clearer) perspective of cancer. Physical Biology. 2011. View in: PubMed

Nagahara, L.A., J.S.H. Lee, L.K. Molnar, N.J. Panaro, D. Farrell, K. Ptak, J. Alper, P. Grodzinski. Strategic Workshops on Cancer Nanotechnology. Cancer Research. 2010. View in: PubMed

Veiseh, O., J.W. Gunn, F. Kievit, C. Sun, C. Feng, J.S.H. Lee, M. Zhang. Inhibition of Tumor Cell Invasion with Chlorotoxin-Bound Superparamagnetic Nanoparticles. Small. 2009. View in: PubMed

Lee, J.S.H., J. Cheng, K.Y. Kim. Next Generation Nanosolutions for Cancer Treatment and Diagnosis. Cancer and Chemotherapy Reviews. 2008. View: here

Sun, C., J.S.H. Lee, M. Zhang. Magnetic Nanoparticles in MR Imaging and Drug Delivery. Advanced Drug Delivery Reviews. 2008. View in: PubMed

Panorchan, P., J.S.H. Lee, B.R. Daniels, T.P. Kole, Y. Tseng, D. Wirtz. Probing Cellular Mechanical Responses to Stimuli Using Ballistic Intracellular Nanorheology. Methods in Cell Biology: Cell Mechanics. 2007. View in: PubMed

Lee, J.S.H., P. Panorchan, C.M. Hale, S.B. Khatau, J. George, C. Stewart, D. Hodzic, D. Wirtz. Nuclear lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration. Biophysical Journal. 2007. View in: PubMed

Lee, J.S.H., P. Panorchan, C.M. Hale, S.B. Khatau, T.P. Kole, Y. Tseng, D. Wirtz. Ballistic Intracellular Nanorheology Reveals ROCK-Hard Cytoplasmic Stiffening Response to Fluid Flow. Journal of Cell Science. 2006. View in: PubMed

Panorchan, P., J.S.H. Lee, Y. Tseng, D. Wirtz. Microrheology and ROCK Signaling of Human Endothelial Cells Embedded in a 3D Matrix. Biophysical Journal. 2006. View in: PubMed

Tseng, Y., T.P. Kole, J.S.H. Lee, E. Fedorov, S.C. Almo, B.W. Schafer, D. Wirtz. How Actin Crosslinking and Bundling Proteins Cooperate to Generate an Enhanced Cell Mechanical Response. Biochemical and Biophysical Research Communications. 2005. View in: PubMed

Lee, J.S.H., M.I. Chang, Y. Tseng, D. Wirtz. Cdc42 Mediates Nucleus Movement and MTOC Polarization in Swiss 3T3 Fibroblasts under Mechanical Shear Stress. Molecular Biology of the Cell. 2005. View in: PubMed

Tseng, Y., J.S.H. Lee, T.P. Kole, I. Jiang, D. Wirtz. Micro-Organization and Visco-elasticity of the Interphase Nucleus Revealed by Particle Nanotracking. Journal of Cell Science. 2004. View in: PubMed

Tseng Y., T.P. Kole, S.H.J. Lee, D. Wirtz. Local Dynamics and Viscoelastic Properties of Cell Biological Systems. Current Opinion in Colloid & Interface Science. 2002. View: here