Jerry S.H. Lee, PhD
Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences | Chief Scientific and Innovation Officer
323 442 0458 | jerry.lee@ellison.usc.edu
Dr. Lee is an Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the University of Southern California Keck School of Medicine and Viterbi School of Engineering. As the Chief Scientific and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine of USC, he provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century. Prior to joining USC, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit. In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues. Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over thirty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.

Research Focus

Cell and tissue biophysics
Cell migration and motility
Data-driven molecular medicine
Adaptive learning healthcare system
ORCiD
Carolina Garri, PhD
Gavin Kress
Jonathan Le
Fakhar Singhera
Maryann Vogelsang, PhD

Education

BS

2001 Biomedical Engineering – Johns Hopkins University, Baltimore, MD

PhD

2006 Chemical and Biomolecular Engineering- Johns Hopkins University, Baltimore, MD  

Awards

National Cancer Institute Director’s Merit Award, 2010 – 2012, 2014 – 2017
NASA Graduate Student Research Fellowship Award, 2004 – 2006
Tau Beta Pi, 2004

Leadership Positions

  • Trustee, Health and Environmental Sciences Institute
  • Appointed Member, National Research Advisory Council to the Secretary, Department of Veterans Affairs
  • Innovation Initiative Member, Health Services Research and Development Scientific Merit Review Board, Department of Veterans Affairs
  • Founding Member, Innovation Policy Forum of the Board on Science, Technology, and Economic Policy, National Academies of Sciences, Engineering, and Medicine (NASEM)
  • Co-founder and Co-chair, Blood Profiling Atlas in Cancer (BloodPAC)
  • Co-founder and Consultant, Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Research Network, Henry M. Jackson Foundation
  • Founding Co-chair, High Content Data Integration Working Group, Biomarkers’ Consortium Cancer Steering Committee, Foundation for the National Institutes of Health
  • National Research Advisory Council, Advisory Committee Management Office
  • Advisory Board Member, Accelerating Therapeutics for Opportunities in Medicine (ATOM) Consortium

Prominent Publications

Lee, J.S.H., K.M. Darcy, H. Hu, Y. Casablanca, T.P. Conrads, C.L. Dalgard, J.B. Freymann, S.E. Hanlon, G.D. Huang, L. Kvecher, G.L. Maxwell, F. Meng, J. Moncur, C. Turner, J.M. Wells, M.D. Wilkerson, K. Zhu, R.B. Ramoni, C.D. Shriver. From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients. Clinical Pharmacology and Therapeutics, 2019. View: here
Lee J.S.H., Kibbe W.A., Grossman R.L. Data Harmonization for a Molecularly Driven Health System. Cell, 2018. View in: PubMed
Lee JS, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D, Wirtz D. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 2007 Oct 1;93(7):2542-52. View in: PubMed
Wu P.H., Aroush D.R., Asnacios A., Chen W.C., Dokukin M.E., Doss B.L., Durand-Smet P., Ekpenyong A., Guck J., Guz N.V., Janmey P.A., Lee J.S.H., Moore N.M., Ott A., Poh Y.C., Ros R., Sander M., Sokolov I., Staunton J.R., Wang N., Whyte G., Wirtz D. A Comparison of Methods to Assess Cell Mechanical Properties. Nature Methods. 2018. View in: PubMed
Keating, S.M., D.L. Taylor, A.L. Plant, E. Litwack, P. Kuhn, E.J. Greenspan, C.M. Hartshorn, C.C. Sigman, G.J. Kelloff, D. Chang, G. Friberg, *J.S.H. Lee, *K. Kuida. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clinical and Translational Science. 2018. View in: PubMed
Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz. Biophysical and Biomolecular Determination of Cellular Age in Humans. Nature Biomedical Engineering. 2017. View: here
Carr, S.A., S.E. Abbatiello, B.L. Ackermann, C. Borchers, B. Domon, E.W. Deutsch, R.P. Grant, A.N. Hoofnagle, R. Huttenhain, J.M. Koomena, D.C. Liebler, T. Liu, B. MacLean, D.R. Mani, E. Mansfield, H. Neubert, A.G. Paulovich, L. Reiter, O. Vitek, R. Aebersold, L. Anderson, R. Bethem, J. Blonder, E. Boja, J. Botelho, M. Boyne, R.A. Bradshaw, A.L. Burlingame, D. Chan, H. Keshishian, E. Kuhn, C. Kinsinger, J.S.H. Lee, S. Lee, R. Moritz, J. Oses-Prieto, N. Rifaio, J. Ritchiep, H. Rodriguez, P.R. Srinivas, R.R. Townsend, J. Van Eyk, G. Whiteley, A. Wiita, S. Weintraubt. Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach. Molecular and Cellular Proteomics. 2014. View in: PubMed
Sun C, Lee JS, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008 Aug 17;60(11):1252-65. 0. View in: PubMed
Lee JS, Panorchan P, Hale CM, Khatau SB, Kole TP, Tseng Y, Wirtz D. Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci. 2006 May 1;119(Pt 9):1760-8. View in: PubMed
Lee JS, Chang MI, Tseng Y, Wirtz D. Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell. 2005 Feb;16(2):871-80. View in: PubMed
Jerry S.H. Lee, PhD
Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences | Chief Scientific and Innovation Officer
323 442 0458 | jerry.lee@ellison.usc.edu
Dr. Lee is an Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the University of Southern California Keck School of Medicine and Viterbi School of Engineering. As the Chief Scientific and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine of USC, he provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century. Prior to joining USC, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit. In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues. Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over thirty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.

Research Focus

Cell and tissue biophysics
Cell migration and motility
Data-driven molecular medicine
Adaptive learning healthcare system
ORCiD
Carolina Garri, PhD
Gavin Kress
Jonathan Le
Fakhar Singhera
Maryann Vogelsang, PhD

Education

BS

2001 Biomedical Engineering – Johns Hopkins University, Baltimore, MD

PhD

2006 Chemical and Biomolecular Engineering- Johns Hopkins University, Baltimore, MD  

Leadership Positions

  • Trustee, Health and Environmental Sciences Institute
  • Appointed Member, National Research Advisory Council to the Secretary, Department of Veterans Affairs
  • Innovation Initiative Member, Health Services Research and Development Scientific Merit Review Board, Department of Veterans Affairs
  • Founding Member, Innovation Policy Forum of the Board on Science, Technology, and Economic Policy, National Academies of Sciences, Engineering, and Medicine (NASEM)
  • Co-founder and Co-chair, Blood Profiling Atlas in Cancer (BloodPAC)
  • Co-founder and Consultant, Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Research Network, Henry M. Jackson Foundation
  • Founding Co-chair, High Content Data Integration Working Group, Biomarkers’ Consortium Cancer Steering Committee, Foundation for the National Institutes of Health
  • National Research Advisory Council, Advisory Committee Management Office
  • Advisory Board Member, Accelerating Therapeutics for Opportunities in Medicine (ATOM) Consortium

Awards

National Cancer Institute Director’s Merit Award, 2010 – 2012, 2014 – 2017
NASA Graduate Student Research Fellowship Award, 2004 – 2006
Tau Beta Pi, 2004

Prominent Publications

Lee, J.S.H., K.M. Darcy, H. Hu, Y. Casablanca, T.P. Conrads, C.L. Dalgard, J.B. Freymann, S.E. Hanlon, G.D. Huang, L. Kvecher, G.L. Maxwell, F. Meng, J. Moncur, C. Turner, J.M. Wells, M.D. Wilkerson, K. Zhu, R.B. Ramoni, C.D. Shriver. From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients. Clinical Pharmacology and Therapeutics, 2019. View: here
Lee J.S.H., Kibbe W.A., Grossman R.L. Data Harmonization for a Molecularly Driven Health System. Cell, 2018. View in: PubMed
Lee JS, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D, Wirtz D. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 2007 Oct 1;93(7):2542-52. View in: PubMed
Wu P.H., Aroush D.R., Asnacios A., Chen W.C., Dokukin M.E., Doss B.L., Durand-Smet P., Ekpenyong A., Guck J., Guz N.V., Janmey P.A., Lee J.S.H., Moore N.M., Ott A., Poh Y.C., Ros R., Sander M., Sokolov I., Staunton J.R., Wang N., Whyte G., Wirtz D. A Comparison of Methods to Assess Cell Mechanical Properties. Nature Methods. 2018. View in: PubMed
Keating, S.M., D.L. Taylor, A.L. Plant, E. Litwack, P. Kuhn, E.J. Greenspan, C.M. Hartshorn, C.C. Sigman, G.J. Kelloff, D. Chang, G. Friberg, *J.S.H. Lee, *K. Kuida. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clinical and Translational Science. 2018. View in: PubMed
Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz. Biophysical and Biomolecular Determination of Cellular Age in Humans. Nature Biomedical Engineering. 2017. View: here
Carr, S.A., S.E. Abbatiello, B.L. Ackermann, C. Borchers, B. Domon, E.W. Deutsch, R.P. Grant, A.N. Hoofnagle, R. Huttenhain, J.M. Koomena, D.C. Liebler, T. Liu, B. MacLean, D.R. Mani, E. Mansfield, H. Neubert, A.G. Paulovich, L. Reiter, O. Vitek, R. Aebersold, L. Anderson, R. Bethem, J. Blonder, E. Boja, J. Botelho, M. Boyne, R.A. Bradshaw, A.L. Burlingame, D. Chan, H. Keshishian, E. Kuhn, C. Kinsinger, J.S.H. Lee, S. Lee, R. Moritz, J. Oses-Prieto, N. Rifaio, J. Ritchiep, H. Rodriguez, P.R. Srinivas, R.R. Townsend, J. Van Eyk, G. Whiteley, A. Wiita, S. Weintraubt. Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach. Molecular and Cellular Proteomics. 2014. View in: PubMed
Sun C, Lee JS, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008 Aug 17;60(11):1252-65. 0. View in: PubMed
Lee JS, Panorchan P, Hale CM, Khatau SB, Kole TP, Tseng Y, Wirtz D. Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci. 2006 May 1;119(Pt 9):1760-8. View in: PubMed
Lee JS, Chang MI, Tseng Y, Wirtz D. Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell. 2005 Feb;16(2):871-80. View in: PubMed